Mikala Egeblad
Assistant Professor

Mikala Egeblad obtained degrees in Medicine (B.S., 1993) and Human Biology (M.Sc., 1996) from the University of Copenhagen, Denmark. Under the mentorship of Dr. Marja Jäättelä at The Danish Cancer Society, she received her Ph.D. in cancer biology (2000). also from the University of Copenhagen. In Dr. Marja Jäättelä’s lab, she worked on receptor tyrosine kinase signaling and apoptosis in breast cancer. In 2001, Mikala Egeblad joined Dr. Zena Werb’s lab at University of California, San Francisco as a postdoctoral fellow. There, she began employing mouse models to understand how the microenvironment influences tumor progression, focusing on innate immune cell responses and protease-mediated extracellular matrix remodeling. With Zena Werb and another postdoctoral fellow, Dr. Andrew Ewald, she also developed methods for using spinning disk confocal microscopy to image tumor-stroma interactions in breast cancer. In 2009, she came to Cold Spring Harbor Laboratory as an Assistant Professor and in 2014, she was promoted to Associated Professor. For her research in breast cancer, she has been awarded the Era of Hope Scholar Award (2014) from the Department of Defense, Congressionally Directed Medical Research Programs; a Career Catalyst Grant from Susan G. Komen for the Cure (2010); and a Young Investigator Grant from the Breast Cancer Alliance (2010). For her work in pancreatic cancer, she has been awarded a career development award from the Pancreatic Cancer Action Network-AACR (2012).

Mario Shields
Postdoctoral Fellow

Mario received his Ph.D. from Northwestern University, Evanston IL, where he examined the role of Snail family of transcription factors and matrix metalloproteinases in pancreatic cancer progression with Dr. Munshi. He joined the Egeblad lab in August 2012 and is currently investigating the role of fibrillar collagen in pancreatic cancer progression. Mario is supported by a fellowship from the American Association for Cancer Research.

Victoria Kuettner
Postdoctoral Fellow

Victoria received her Ph.D. from the University of Freiburg, Germany, where she investigated the role of collagen VII in the extracellular matrix of dermal fibroblasts with Prof. Leena Bruckner-Tuderman and Prof. Joern Dengjel. Joining the lab in July 2014, she is studying extracellular vesicle-mediated tumor-stroma communication in breast cancer. Victoria is supported by a fellowship from DFG.

Jean Albrengues
Postdoctoral Fellow

Jean received his Ph.D. from the University of Nice-Sophia Antipolis, France. There, he focused on the role of the cytokine LIF during the activation and the epigenetic maintenance of pro-invasive fibroblasts, under the direction of Dr. Cedric Gaggioli. He joined the Egeblad lab in May 2015, and is working on determining how communications between tumor cells and neutrophils contribute to breast cancer cell dormancy and recurrence.

Lindsay Puckett
Visiting Research Fellow

Dr. Lindsay Puckett received her MD from St. Georges University in 2012. She is currently a 4th year Radiation Oncology resident at Northwell Health. She joined the Egeblad lab in August 2016 as a visiting research fellow and is currently investigating immune response to radiation in a murine breast cancer model. Lindsay’s fellowship is supported through the collaborative partnership between Northwell Health and Cold Spring Harbor Laboratory.

Xuyan He
Postdoctoral Fellow

Xueyan received her Ph.D. from Model Animal Research Center of Nanjing University, China. There, she examined the role of p53 in tumor microenvironment using genetically engineered mouse models, under the direction of Professor Geng Liu. She joined the Egeblad lab in September 2016 and is currently investigating the interactions and signaling pathways between cancer cells and tumor stroma cells, (especially T cells and dendritic cells). She is interested in mechanisms of immune suppression and cancer immunotherapy.

Miriam Fein
Graduate Student, Stony Brook University 

Miriam received her M.A. from Hunter College in Molecular, Cell, and Developmental Biology. She joined the Genetics program of Stony Brook University in 2010, and subsequently joined the Egeblad lab in 2011. She is studying tumor-host interactions that drive tumorigenesis and metastasis using intravital imaging in mouse models. 

Laura Maiorino
Graduate Student, Watson School of Biological Sciences

Laura received her M.S in Medical, Molecular and Cellular Biotechnology from the San Raffaele University in Milan, Italy. Since 2013 she is a graduate student in the Watson School of Biological Sciences at Cold Spring Harbor Laboratory. She joined the Egeblad Lab in 2014 to study the molecular pathways underlying organ specificity and dormancy of liver metastasis.

Emilis Bruzas
Graduate Student, Watson School of Biological Sciences

Emilis obtained his BA in Natural Sciences with a concentration in Biochemistry from the University of Cambridge in 2014. He joined the Watson School of Biological Sciences the same year and has been a member of the Egeblad lab since 2015. Emilis studies the interplay between the immune system and stem cell behavior in a model of breast cancer dormancy.

Jacqueline Cappellani
Laboratory Technician

Jacqueline received her B.S in Marine Science from the University of Maine. She joined the Egeblad lab in 2011 and manages the lab, maintains the mouse colonies, and administers and measures response to various therapeutic treatments.

Margie Bell
Administrative Assistant 

Margie is the Egeblad lab’s administrative assistant in addition to being the Administrative & Regulatory Coordinator for CSHL Cancer Center.